High-Dose of ADHD Drugs Linked to Higher Risks of Psychosis and Mania

Published on September 12, 2024

People taking high doses of amphetamines, often prescribed for treating attention-deficit hyperactivity disorder (ADHD), may have higher risks of developing psychosis and mania, a new study found. Researchers at McLean Hospital, the largest psychiatric affiliate of Harvard Medical School, found that people taking high doses of the stimulant amphetamine, the active ingredient in ADHD drugs such as Adderall, face a 5.3-fold higher chance of experiencing a psychotic or manic episode. “Stimulant medications don’t have an upper dose limit on their labels,” Dr. Lauren Moran, a pharmacoepidemiology researcher at McLean Hospital and lead author of the study, said in a press release. “Our results show that it is clear that dose is a factor in psychosis risk and should be a chief consideration when prescribing stimulants.”...

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