UCSF Researchers Identify Major Driver Behind COVID and Long COVID, With Potential Treatment

Published on August 28, 2024

Researchers at the University of California San Francisco have identified fibrin, a natural protein involved in blood clotting, as a major driver of the COVID-19 disease, according to a new study. Fibrin binds to proteins from the SARS-CoV-2 virus to form blood clots that are difficult to break down, the authors found. This clotting then drives the various inflammatory and neurological symptoms seen in COVID-19 and long COVID, the researchers found. Previous studies have theorized that blood clotting is a consequence of inflammation. However, the new Nature study, published on Wednesday, shows the reverse: that the clotting comes first. “We know of many other viruses that unleash a similar cytokine storm in response to infection, but without causing blood clotting activity like we see with COVID,” Dr. Warner Greene, senior investigator and director emeritus at Gladstone and co-author of the study, said in a press release....

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