Pig Kidney Transplanted Into Human for First Time

Published on March 23, 2024

The gene-edited kidney of a pig has been transplanted into a human successfully for the first time, with the animal being genetically modified to make the organ compatible. The 4-hour surgery was conducted at the Massachusetts General Hospital (MGH) on March 16, according to an MGH press release on Thursday. The kidney came from a pig that underwent 69 genomic edits to remove “harmful pig genes” and add “certain human genes to improve its compatibility with humans.” The edits, made using CRISPR-Cas9 technology, were done to ensure that the human body would not reject the foreign kidneys. In addition, “scientists inactivated porcine endogenous retroviruses in the pig donor to eliminate any risk of infection in humans.” The kidney recipient, Mr. Richard Slayman of Weymouth, Massachusetts, is “recovering well” at the hospital and is expected to be discharged soon....

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